Thrombosis related to emergency factor VIIa treatment

Use of recombinant factor VIIa for emergency reversal of anticoagulation.

CONTEXT There is limited data regarding the use of activated recombinant factor VII (rFVIIa) in anticoagulated patients requiring reversal. AIMS To identify and describe characteristics of subjects who received rFVIIa as part of emergency treatment aimed at improving hemostasis. SETTINGS AND DESIGN Data was obtained from an international peer-reviewed registry haemostasis.com. This registry...

Binding of factor VIIa to tissue factor permits rapid antithrombin III/heparin inhibition of factor VIIa.

Because free factor VIIa is inactivated only very slowly by a plasma concentration of antithrombin III (AT III) even in the presence of heparin, it has been assumed that AT III plays no significant role in regulating the initiation of tissue factor-dependent blood coagulation. However, in the present study, we present evidence that factor VIIa bound to tissue factor, unlike free factor VIIa, is...

Factor VIIA determination compared to D-Dimer in diagnosis of deep venous thrombosis.

Tisssue factor and factor viia cross-species compatibility Tisssue factor and factor viia cross-species compatibility

1. Astract 2. Introduction 3. TF and FVIIa 3.1. Purification, cloning and expression of TF 3.2. TF structure and function 3.3. Purification, cloning and expression of FVII 3.4. FVIIa structure and function 3.5. Interaction of FVIIa with TF 3.6. Binding of human FVIIa to sTF, lipidated TF and cell surface TF 3.6.1. FVIIa binding to sTF 3.6.2. FVIIa binding to lipidated TF and to cell surface TF ...

The evidence behind inhibitor treatment with recombinant factor VIIa.

Over the past 10 years considerable use has been made of recombinant factor VIIa (rFVIIa) for the treatment of patients with inhibitors to coagulation factors. During this time, its place in the management of acute bleeds and surgery has become better defined. Although pharmacokinetic studies report the half-life of rFVIIa as 2.7 h, there is considerable intersubject variability. Moreover, rFVI...